PAMAM Dendrimer G4.0 Amidoethanol (water solution)

PAMAM dendrimer G4.0 amidoethanol (PAMAM G4.0 amidoethanol) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini that has been used as a drug delivery system in vivo.¹ It is approximately 45 Å in diameter and has 64 surface groups.² Conjugates of PAMAM G4.0 amidoethanol and the synthetic glucocorticoid methylprednisolone (Item No. 15013) decrease ovalbumin-induced increases in the number of eosinophils in bronchoalveolar lavage fluid (BALF) and lung tissue to a greater extent than methylprednisolone alone in a mouse model of lung inflammation.¹ PAMAM G4.0 amidoethanol is toxic to the cyanobacteria Anabaena and green alga C. reinhardtii (EC₉₀s = 5.13 and 1.02 mg/L, respectively) and induces the formation of reactive oxygen species (ROS) in both.³ Unlike PAMAM G3.0, -G4.0, -G5.0, and -G6.0-NH₂, PAMAM G4.0 amidoethanol is unable to transfect cells.⁴

WARNING This product is not for human or veterinary use.

1. Inapagolla, R., Guru, B.R., Kurtoglu, Y.E., et al. In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation. Int. J. Pharm. 399(1-2), 140-147 (2012).

2. Bai, L., Wan, H., and Street, S.C. Preparation of ultrafine FePt nanoparticles by chemical reduction in PAMAM-OH template. Colloids Surf. A Physicochem. 349(1-3), 23-28 (2009).

3. Gonzalo, S., Rodea-Palomares, I., Leganés, F., et al. First evidences of PAMAM dendrimer internalization in microorganisms of environmental relevance: A linkage with toxicity and oxidative stress. Nanotoxicology 9(6), 706-718 (2015).

4. Shakhbazau, A., Isayenka, I., Kartel, N., et al. Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity. Int. J. Pharm. 383(1-2), 228-235 (2010).