A hydroxy-terminated PAMAM dendrimer
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PAMAM Dendrimer G5.0 Amidoethanol (water solution)

Item No. 39114

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM 5.0 Amidoethanol
  • Polyamidoamine Dendrimer G5.0 Amidoethanol
Molecular Formula
[NH2(CH2)2NH2]:(G=5);dendri PAMAM(NHCH2CH2OH)128
Formula Weight
28950.9
Formulation (Request formulation change)
A solution in water
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $292

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    Product Description

    PAMAM dendrimer G5.0 amidoethanol (PAMAM G3.0-amidoethanol ) is a polyamidoamine (PAMAM) dendrimer with hydroxyl termini.1 It is approximately 51 Å in diameter in PBS and has 128 surface groups. PAMAM G3.0-amidoethanol dendrimers encapsulating gold nanoparticles induce oxidation of carbon monoxide in a cell-free assay.2 It binds to bilirubin (Kd = 8.5 µM).3 PAMAM G5.0 aminoethanol is active against S. aureus.4 It inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.5 PAMAM G3.0-amidoethanol has been used in the formation and isolation of platinum nanoclusters for in vitro breast cancer subtyping.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012).

    2. Kracke, P., Haas, T., Saltsburg, H., et al. CO oxidation on unsupported dendrimer-encapsulated gold nanoparticles. J. Phys. Chem. C 114(39), 16401-16407 (2010).

    3. Shcharbin, D., and Bryszewska, M. Complex formation between endogenous toxin bilirubin and polyamidoamine dendrimers: A spectroscopic study. Biochim. Biophys. Acta 1760(7), 1021-1026 (2006).

    4. Altaher, Y., and Kandeel, M. Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureus. J. Nanomater. 4013016 (2022).

    5. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    6. Tanaka, S.-i., Wadati, H.S., K., Yasuda, H., et al. Red-fluorescent Pt nanoclusters for detecting and imaging HER2 in breast cancer cells. ACS Omega 5(37), 23718-23723 (2020).