A prolyl endopeptidase inhibitor
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HUP-55

Item No. 39117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-[4-methyl-2-(3-phenylpropyl)-5-oxazolyl]-2-pyrrolidinecarbonitrile
CAS Number
3006795-68-9
Molecular Formula
C18H21N3O
Formula Weight
295.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: 10 mg/ml
SMILES
CC1=C(N2[C@H](C#N)CCC2)OC(CCCC3=CC=CC=C3)=N1
InChi Code
InChI=1S/C18H21N3O/c1-14-18(21-12-6-10-16(21)13-19)22-17(20-14)11-5-9-15-7-3-2-4-8-15/h2-4,7-8,16H,5-6,9-12H2,1H3/t16-/m0/s1
InChi Key
FEEUIAMWBWZZNX-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $40

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    5 mg

    $139

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    10 mg

    $237

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    Product Description

    HUP-55 is an inhibitor of prolyl endopeptidase (IC50 = 5 nM).1 It reduces α-synuclein dimerization in Neuro2a cells, induces autophagy in HEK293 cells, and decreases hydrogen peroxide-induced increases in reactive oxygen species (ROS) production in SH-SY5Y cells when used at a concentration of 10 µM. HUP-55 (10 mg/kg) decreases ipsilateral paw use and striatal oligomeric α-synuclein levels in a mouse model of Parkinson’s disease induced by adenoviral delivery of an α-synuclein-encoding vector (AAV-αSyn).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kilpeläinen, T.P., Pätsi, H.T., Svarcbahs, R., et al. Nonpeptidic oxazole-based prolyl oligopeptidase ligands with disease-modifying effects on α-synuclein mouse models of Parkinson’s disease. J. Med. Chem. 66(11), 7475-7496 (2023).