A succinamic acid-terminated PAMAM dendrimer
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PAMAM Dendrimer G2.0 Succinamic Acid (water solution)

Item No. 39119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM G2.0 Succinamic Acid
  • Polyamidoamine Dendrimer G2.0 Succinamic Acid
Formula Weight
4856.0
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    500 mg

    $98

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    1 g

    $186

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    Product Description

    PAMAM dendrimer G2.0 succinamic acid (PAMAM G2.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini.1 It has 16 surface groups. PAMAM G2.0 succinamic acid is an antagonist for the pore-forming channels anthrax toxin protective antigen 63 (PA63; IC50 = 879 nM) in lipid bilayers.2 It is active against S. aureus.3 PAMAM G2.0 succinamic acid inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    2. Yamini, G., Kalu, N., and Nestorovich, E.M. Impact of dendrimer terminal group chemistry on blockage of the anthrax toxin channel: A single molecule study. Toxins (Basel) 8(11), 337 (2016).

    3. Altaher, Y., and Kandeel, M. Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureus. J. Nanomater. 4013016 (2022).