A succinamic acid-terminated PAMAM dendrimer
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PAMAM Dendrimer G3.0 Succinamic Acid (water solution)

Item No. 39120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM G3.0 Succinamic Acid
  • Polyamidoamine Dendrimer G3.0 Succinamic Acid
Formula Weight
10109.0
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $142

    Add

    1 g

    $270

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    PAMAM dendrimer G3.0 succinamic acid (PAMAM G3.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini that has been used as a drug delivery system in vivo.1 It is approximately 35 Å in diameter in PBS and has 32 surface groups.2,3 PAMAM G3.0 succinamic acid (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in infected Vero cells.3 It is active against S. aureus.4 Intravenous administration of PAMAM G3.0 succinamic acid conjugated to the tubulin polymerization inhibitor combretastatin A4 (combrestatin A4; Item No. 10007412) increases intratumoral necrosis and decreases intratumoral blood flow in an orthotopic U251 glioma rat xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gonawala, S., Aryal, M., Ewing, J.R., et al. MRI monitoring of cerebral blood flow after the delivery of nanocombretastatin across the blood brain tumor barrier. J. Nanomed. Nanotechnol. 9(5), 516 (2018).

    2. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012).

    3. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    4. Altaher, Y., and Kandeel, M. Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureus. J. Nanomater. 4013016 (2022).