A succinamic acid-terminated PAMAM dendrimer
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PAMAM Dendrimer G4.0 Succinamic Acid (water solution)

Item No. 39121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PAMAM G4.0 Succinamic Acid
  • Polyamidoamine Dendrimer G4.0 Succinamic Acid
Formula Weight
20615.0
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

    $208

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    1 g

    $374

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    Product Description

    PAMAM dendrimer G4.0 succinamic acid (PAMAM G4.0-SAH) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini that has been used as a drug delivery system in vitro and in vivo.1,2 It is approximately 45 Å in diameter in PBS and has 64 surface groups.3,4 PAMAM G4.0-SAH (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in infected Vero cells.4 It is active against S. aureus.5 Lipid-dendrimer hybrid nanoparticles containing PAMAM G4.0-SAH and encapsulating the glycopeptide antibiotic vancomycin (Item No. 15327) are active against S. aureus and methicillin-resistant S. aureus (MRSA).1 In vivo, PAMAM G4.0-SAH conjugated to the monosaccharide sialic acid, also known as N-acetylneuraminic acid (Neu5Ac), prevents infection by the influenza A subtype H3N2 in a mouse model of pneumonitis when administered at a dose of 9 µg/g.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sonawane, S.J., Kalhapure, R.S., Rambharose, S., et al. Ultra-small lipid-dendrimer hybrid nanoparticles as a promising strategy for antibiotic delivery: In vitro and in silico studies. Int. J. Pharm. 504(1-2), 1-10 (2016).

    2. Landers, J.J., Cao, Z., Lee, I., et al. Prevention of influenza pneumonitis by sialic acid-conjugated dendritic polymers. J. Infect. Dis. 186(9), 1222-1230 (2002).

    3. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012).

    4. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    5. Altaher, Y., and Kandeel, M. Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureus. J. Nanomater. 4013016 (2022).