A succinamic acid-terminated PAMAM dendrimer
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PAMAM Dendrimer G5.0 Succinamic Acid (water solution)

Item No. 39122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Polyamidoamine Dendrimer G5.0 Succinamic Acid
  • PAMAM G5.0 Succinamic Acid
Formula Weight
41626.0
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: soluble
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

    $286

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    Product Description

    PAMAM dendrimer G5.0 succinamic acid (PAMAM G5.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini.1 It is approximately 59 Å in diameter and has 128 surface groups.1,2 PAMAM G5.0 succinamic acid inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.1 It is active against S. aureus.3 PAMAM G5.0 succinamic acid encapsulating the anthracycline antitumor antibiotic doxorubicin (Item No. 15007) decreases cell viability in KB epithelial carcinoma cells.4 It does not induce mortality in zebrafish, unlike PAMAM dendrimer G6.0 amine (Item No. 39076) or PAMAM dendrimer G6.0 succinamic acid (Item No. 39123), when used at a concentration of 250 ppm in the tank water.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kandeel, M., Al-Taher, A., Park, B.K., et al. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus. J. Med. Virol. 92(9), 1665-1670 (2020).

    2. Dobrovolskaia, M.A., Patri, A.K., Simak, J., et al. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro. Mol. Pharm. 9(3), 382-393 (2012).

    3. Altaher, Y., and Kandeel, M. Structure-activity relationship of anionic and cationic polyamidoamine (PAMAM) dendrimers against Staphylococcus aureus. J. Nanomater. 4013016 (2022).

    4. Zhang, M., Guo, R., Kéri, M., et al. Impact of dendrimer surface functional groups on the release of doxorubicin from dendrimer carriers. J. Phys. Chem. B 118(6), 1696-1706 (2014).

    5. Pryor, J.B., Harper, B.J., and Harper, S.L. Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish. Int. J. Nanomedicine 9, 1947-1956 (2014).