A biotinylated fibrinogen peptide
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Fibrinogen (β chain) (41-62)-biotin Peptide

Item No. 39127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Biotin-Phe-Ser-Ala-Arg-Gly-His-Arg-Pro-Leu-Asp-Lys-Lys-Arg-Glu-Glu-Ala-Pro-Ser-Leu-Arg-Pro-Ala
  • FGB
MW
2,745.1
Formulation (Request formulation change)
1 mg of lyophilized peptide
Peptide Sequence
Biotin-FSARGHRPLDKKREEAPSLRPA
UniProt Accession №
P02675
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $247

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    Product Description

    Fibrinogen (β chain) (41-62)-biotin peptide is a biotinylated version of the secreted matrix protein fibrinogen, which undergoes citrullination and has been found as the citrullinated form in plasma circulating immune complexes of patients with rheumatoid arthritis.1 Fibrinogen is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) and PAD4, which can occur in the synovial fluid from patients with rheumatoid arthritis.2,3 Cayman's Fibrinogen (β Chain) (41-62)-biotin Peptide is intended for use as a negative control in the detection of autoantibodies against citrullinated fibrinogen and is the non-citrullinated form of Citrullinated Fibrinogen (R44 + R47 + R60) (41-62)-biotin Peptide (Item No. 39128)

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, X., Okeke, N.L., Sharpe, O., et al. Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. Arthritis Res. Ther. 10(4), R94 (2008).

    2. Damiana, T., Damgaard, D., Sidelmann, J.J., et al. Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure. Clin. Chim. Acta 501, 6-11 (2020).

    3. Damgaard, D., Senolt, L., Nielsen, M.F., et al. Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen. Arthritis Res. Ther. 16(6), 498 (2014).