A biotinylated and citrullinated fibrinogen peptide
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Citrullinated Fibrinogen (β chain) (R44 + R47 + R60) (41-62)-biotin Peptide

Item No. 39128

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formula Weight
2747.9
Formulation (Request formulation change)
1 mg of lyophilized peptide
Peptide Sequence
Biotin-FSAXGHXPLDKKREEAPSLXPA (X=Citrulline)
UniProt Accession №
P02675
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $247

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    Product Description

    Citrullinated fibrinogen (β chain) (R44 + R47 + R60) (41-62)-biotin peptide is a biotinylated version of a tri-citrullinated form of the secreted matrix protein fibrinogen, which has been found as the citrullinated form in plasma circulating immune complexes of patients with rheumatoid arthritis.1 Fibrinogen is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) and PAD4, which can occur in the synovial fluid from patients with rheumatoid arthritis.2,3 Cayman's Citrullinated Fibrinogen (β Chain) (R44 + R47 + R60) (41-62)-biotin Peptide is intended for the detection of autoantibodies against fibrinogen citrullinated at R44, R47, and R60.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, X., Okeke, N.L., Sharpe, O., et al. Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. Arthritis Res. Ther. 10(4), R94 (2008).

    2. Damiana, T., Damgaard, D., Sidelmann, J.J., et al. Citrullination of fibrinogen by peptidylarginine deiminase 2 impairs fibrin clot structure. Clin. Chim. Acta 501, 6-11 (2020).

    3. Damgaard, D., Senolt, L., Nielsen, M.F., et al. Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen. Arthritis Res. Ther. 16(6), 498 (2014).