A DNA alkylating agent
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Semustine

Item No. 39133

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-chloroethyl)-N′-(4-methylcyclohexyl)-N-nitroso-urea
CAS Number
13909-09-6
Synonyms
  • MeCCNU
  • methyl-CCNU
  • methyl-Lomustine
Molecular Formula
C10H18ClN3O2
Formula Weight
247.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=NN(CCCl)C(NC1CCC(CC1)C)=O
InChi Code
InChI=1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)
InChi Key
FVLVBPDQNARYJU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

    $209

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    10 mg

    $343

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    25 mg

    $570

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    Cayman Chemical
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    Product Description

    Semustine is a DNA alkylating agent.1 It induces DNA cross-linking in isolated calf thymus DNA when used at a concentration of 2 mM. Semustine induces cytotoxicity in three patient-derived astrocytoma cell lines in a concentration-dependent manner.2 It increases survival in a patient-derived xenograft (PDX) mouse model of brain cancer when administered at a dose of 30 mg/kg twice per week.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brent, T.P. Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts. Cancer Res. 44(5), 1887-1892 (1984).

    2. Rubin, N.H., Casartelli, C., Macik, B.G., et al. In vitro cellular characteristics and survival responses of human astrocytoma clones to chloroethyl-nitrosoureas and dianhydrogalactitol. Invest New Drugs 1(2), 129-137 (1983).

    3. Shapiro, W.R., Basler, G.A., Chernik, N.L., et al. Human brain tumor transplantation into nude mice. J. Natl. Cancer Inst. 62(3), 447-453 (1979).