A disulfide-linked derivative of D-pantothenic acid
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D-Pantethine

Item No. 39137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,2′R)-N,N′-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-butanamide
CAS Number
16816-67-4
Molecular Formula
C22H42N4O8S2
Formula Weight
554.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Slightly soluble
SMILES
OCC(C)(C)[C@@H](O)C(NCCC(NCCSSCCNC(CCNC([C@H](O)C(C)(C)CO)=O)=O)=O)=O
InChi Code
InChI=1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1
InChi Key
DJWYOLJPSHDSAL-ROUUACIJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    Product Description

    D-Pantethine is a disulfide-linked derivative of the coenzyme A biosynthetic precursor D-pantothenic acid (Item No. 17288).1 It reduces cell death, the percent of infected cells, nucleocapsid protein (N protein) levels, and spike glycoprotein (S protein), also known as surface glycoprotein, levels in Vero E6 cells infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when used at concentrations of 100 or 250 µM. It decreases the cholesterol-to-protein ratio in uninfected Vero E6 cells, but not SARS-CoV-2-infected Vero E6 cells, when used at a concentration of 250 µM. Dietary administration of D-pantethine (18.2 mg/kg in the diet) increases body weight gain in rats fed a D-pantothenic acid-deficient diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abou-Hamdan, M., Saleh, R., Mani, S., et al. Potential antiviral effects of pantethine against SARS-CoV-2. Sci. Rep. 13(1), 2237 (2023).

    2. Shibata, K., Kaneko, M., and Fukuwatari, T. D-pantethine has vitamin activity equivalent to D-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 59(2), 93-99 (2013).