A synthetic tetrapeptide with anti-aging activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Epitalon (trifluoroacetate salt)

Item No. 39177

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-α-glutamyl-L-α-aspartyl-glycine, trifluoroacetate salt
Synonyms
  • Ala-Glu-Asp-Gly
Molecular Formula
C14H22N4O9 • XCF3COOH
Formula Weight
390.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
AEDG
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 3 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
OC(CC[C@H](NC([C@H](C)N)=O)C(N[C@H](C(NCC(O)=O)=O)CC(O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C14H22N4O9.C2HF3O2/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24;3-2(4,5)1(6)7/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24);(H,6,7)/t6-,7-,8-;/m0./s1
InChi Key
RJCJYCJZMHAFCM-WQYNNSOESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $33

    Add

    25 mg

    $79

    Add

    50 mg

    $148

    Add

    100 mg

    $261

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Epitalon is a synthetic tetrapeptide with anti-aging activities.1,2,3,4 It increases the lifespan of D. melanogaster imagoes when used at concentrations ranging from 0.001 to 5% in the culture medium.1 Epitalon (1 μg/animal) delays age-related estrous cycle shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice when administered at a dose of 0.1 µg/animal.3 Epitalon (10 µg/animal) also stimulates melatonin synthesis in the evening and restores the circadian rhythm of cortisol secretion in senescent M. mulatta monkeys.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khavinson, V.K., Izmaylov, D.M., Obukhova, L.K., et al. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech. Ageing Dev. 120(1-3), 141-149 (2000).

    2. Anisimov, V.N., Khavinson, V.K., Popovich, I.G., et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology 4(4), 193-202 (2003).

    3. Kossoy, G., Anisimov, V.N., Ben-Hur, H., et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo 20(2), 253-257 (2006).

    4. Khavinson, V., Goncharova, N., and Lapin, B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro. Endocrinol. Lett. 22(4), 251-254 (2001).