An ionizable cationic lipid
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Lipid III-45

Item No. 39243

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butyl-octanoic acid, 1,1′-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester
CAS Number
2096984-25-5
Synonyms
  • ALC-0366
  • Cationic Lipid A
Molecular Formula
C45H89NO5
Formula Weight
724.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 10 mg/ml
SMILES
OCCCN(CCCCCCCCCOC(C(CCCC)CCCCCC)=O)CCCCCCCCCOC(C(CCCC)CCCCCC)=O
InChi Code
InChI=1S/C45H89NO5/c1-5-9-13-25-34-42(32-11-7-3)44(48)50-40-29-23-19-15-17-21-27-36-46(38-31-39-47)37-28-22-18-16-20-24-30-41-51-45(49)43(33-12-8-4)35-26-14-10-6-2/h42-43,47H,5-41H2,1-4H3
InChi Key
WKWZZCCOOBPOOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

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    Product Description

    Lipid III-45 is an ionizable cationic lipid (pKa = 6.25).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1,2,3 LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice.1,2 LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting the tumor-associated antigen and tight junction integral protein claudin-18 isoform 2 (claudin-18.2) to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ansell, S.M., and Du, X. Lipids and lipid nanoparticle formulations for delivery of nucleic acids. US 10,166,298 B2, (2019).

    2. Lin, J.C.P., and Tam, Y. Lipid delivery of therapeutic agents to adipose tissue. (2018).

    3. Sahin, U., Lindemann, C., Diekmann, J., et al. RNA compositions targeting claudin-18.2. (2021).