Syringetin

Syringetin is a methylated flavonol that has been found in G. biloba and has diverse biological activities.^1,2,3 It inhibits α-glucosidase and scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay (IC₅₀s = 36.8 and 12.3 µM, respectively).^1,3 Syringetin (50 µM) reduces the proliferation of, induces cell cycle arrest at the G₂/M phase in, and decreases cyclin D1 and COX-2 levels in, Caco-2 colorectal adenocarcinoma cells.² It increases the lifespan of C. elegans when used at a concentration of 100 µM.³

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1. Wu, B., Song, H.-P., Zhou, X., et al. Screening of minor bioactive compounds from herbal medicines by in silico docking and the trace peak exposure methods. J. Chromatogr. A 1436, 91-99 (2016).

2. Gómez-Alonso, S., Collins, V.J., Vauzour, D., et al. Inhibition of colon adenocarcinoma cell proliferation by flavonols is linked to a G₂/M cell cycle block and reduction in cyclin D1 expression. Food Chem. 130(3), 493-500 (2012).

3. Büchter, C., Ackermann, D., Honnen, S., et al. Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16. Food Funct. 6(10), 3383-3392 (2015).