A steroid saponin with anticancer activity
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Chonglou Saponin VII

Item No. 39251

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
CAS Number
68124-04-9
Synonyms
  • Paris Saponin VII
  • PS VII
Molecular Formula
C51H82O21
Formula Weight
1031.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
[H][C@]1(C[C@@]2(O[C@]3([C@H]([C@@]24O)C)OC[C@@H](CC3)C)[H])[C@@]5(CC=C6C[C@@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@@H]([C@@H](CO)O7)O[C@@H]9O[C@H]([C@@H]([C@H]([C@H]9O)O)O[C@@H]%10O[C@H]([C@@H]([C@H]([C@H]%10O)O)O)C)C)CC[C@@]6([C@@](CC[C@@]14C)5[H])C)[H]
InChi Code
InChI=1S/C51H82O21/c1-20-10-15-50(63-19-20)24(5)51(62)31(72-50)17-29-27-9-8-25-16-26(11-13-48(25,6)28(27)12-14-49(29,51)7)67-47-43(71-45-38(59)35(56)33(54)22(3)65-45)40(61)42(30(18-52)68-47)70-46-39(60)36(57)41(23(4)66-46)69-44-37(58)34(55)32(53)21(2)64-44/h8,20-24,26-47,52-62H,9-19H2,1-7H3/t20-,21+,22+,23+,24-,26+,27-,28+,29+,30-,31+,32+,33+,34-,35-,36+,37-,38-,39-,40+,41+,42-,43-,44+,45+,46+,47-,48+,49+,50-,51-/m1/s1
InChi Key
FBFJAXUYHGSVFN-IYUYFXHASA-N
Origin
Plant/Paris polyphylla
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $107

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    5 mg

    $427

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    10 mg

    $588

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    Product Description

    Chonglou saponin VII is a steroid saponin that has been found in P. polyphylla and has anticancer activities.1 It also inhibits the proliferation of MDA-MB-231, MDA-MB-436, and MCF-7 breast cancer cells (IC50s = 3.16, 3.45, and 2.86 µM, respectively).1 It induces apoptosis and autophagosome formation in the same cells. Chonglou saponin VII (1.5 mg/kg) induces intratumoral autophagy and reduces tumor growth in an MDA-MB-231 mouse xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiang, Y.-C., Peng, P., Liu, X.-W., et al. Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells. Acta Pharmacol. Sin. 43(6), 1568-1580 (2022).