Mogrol

Mogrol is an aglycone form of various mogrosides that has been found in S. grosvenorii and has diverse biological activities.^1,2,3 It inhibits the proliferation and migration of A549, H1299, H1975, and SK-MES-1 lung cancer cells when used at concentrations ranging from 10 to 50 µM.¹ Mogrol (50 µM) induces AMPK activation and autophagy, as well as apoptosis and cell cycle arrest at the G₁ phase in A549 cells. In vivo, mogrol (10 mg/kg) reduces tumor weight and volume in an A549 mouse xenograft model. Mogrol (5 mg/kg) reduces colonic inflammatory cell infiltration and colonic shortening in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; Item No. 23250).² It also improves LPS-induced memory impairments and decreases hippocampal and frontal cortex levels of TNF-α, IL-1β, and IL-6 in LPS-challenged mice.³

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1. Li, H., Liu, L., Chen, H.-Y., et al. Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis. Toxicol. Appl. Pharmacol. 444, 116037 (2022).

2. Liang, H., Cheng, R., Wang, J., et al. Mogrol, an aglycone of mogrosides, attenuates ulcerative colitis by promoting AMPK activation. Phytomedicine 81, 153427 (2021).

3. Wang, H., Meng, G.-L., Zhang, C.-T., et al. Mogrol attenuates lipopolysaccharide (LPS)-induced memory impairment and neuroinflammatory responses in mice. J. Asian Nat. Prod. Res. 22(9), 864-878 (2020).