An ACE inhibitor and a prodrug form of spiraprilat
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Spirapril (hydrochloride)

Item No. 39278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, monohydrochloride
CAS Number
94841-17-5
Synonyms
  • SCH 33844
Molecular Formula
C22H30N2O5S2 • HCl
Formula Weight
503.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
SMILES
O=C([C@H](C1)N(C([C@@H](N[C@@H](CCC2=CC=CC=C2)C(OCC)=O)C)=O)CC31SCCS3)O.Cl
InChi Code
InChI=1S/C22H30N2O5S2.ClH/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27;/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27);1H/t15-,17-,18-;/m0./s1
InChi Key
CLDOLNORSLLQDI-OOAIBONUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $91

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    10 mg

    $172

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    25 mg

    $406

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    50 mg

    $722

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    Product Description

    Spirapril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 67 nM) and a prodrug form of spiraprilat.1,2 It inhibits the angiotensin I-induced pressor response in rats and dogs with half-maximal inhibitory dose (ID50) values of 16 and 262 µg/kg, respectively.1 Spirapril (5 mg/kg) decreases systolic blood pressure and left ventricular hypertrophy and induces angiogenesis in spontaneously hypertensive rats.2 Formulations containing spirapril have previously been used in the treatment of hypertension and congestive heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sybertz, E.J., Watkins, R.W., Ahn, H.S., et al. Pharmacologic, metabolic, and toxicologic profile of spirapril (SCH 33844), a new angiotensin converting inhibitor. J. Cardiovasc. Pharmacol. 10 Suppl 7, S105-108 (1987).

    2. Olivetti, G., Cigola, E., Lagrasta, C., et al. Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 21(3), 362-370 (1993).