A cucurbitane glycoside with anti-inflammatory activity
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Mogroside IIIE

Item No. 39286

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,9β,10α,11α,24R )-3-(β-D-glucopyranosyloxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
88901-37-5
Synonyms
  • MGIIIE
Molecular Formula
C48H82O19
Formula Weight
963.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
C[C@]12[C@](CC=C3[C@@]2([H])CC[C@@H](C3(C)C)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O)([H])[C@]5([C@](C[C@H]1O)([C@]([C@@H](CC[C@H](C(O)(C)C)O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C)([H])CC5)C)C
InChi Code
InChI=1S/C48H82O19/c1-21(9-13-31(45(4,5)61)66-43-40(37(58)34(55)27(20-51)64-43)67-42-39(60)36(57)33(54)26(19-50)63-42)22-15-16-46(6)28-12-10-23-24(48(28,8)29(52)17-47(22,46)7)11-14-30(44(23,2)3)65-41-38(59)35(56)32(53)25(18-49)62-41/h10,21-22,24-43,49-61H,9,11-20H2,1-8H3/t21-,22-,24-,25-,26-,27-,28+,29-,30+,31-,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,46+,47-,48+/m1/s1
InChi Key
QATISCJMIITVAB-CNEPTXDISA-N
Origin
Plant/Siraitia grosvenorii (Swingle)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $72

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    5 mg

    $286

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    10 mg

    $466

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    25 mg

    $984

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    Cayman Chemical
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    Product Description

    Mogroside IIIE is a cucurbitane glycoside that has been found in S. grosvenorii and has anti-inflammatory activity.1,2 It inhibits LPS-induced secretion of IL-1β, IL-6, and Tnf-α from, as well as LPS-induced increases in toll-like receptor 4 (TLR4) levels in, RAW 264.7 macrophages when used at a concentration of 50 µM.1 Mogroside IIIE (20 mg/kg) increases in bronchoalveolar lavage fluid (BALF) levels of IL-1β, IL-6, and TNF-α, and increases in lung tissue myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury. It decreases lung fibrosis, as well as increases animal survival and reduces lung levels of matrix metalloproteinase-9 (MMP-9), in a mouse model of pulmonary fibrosis induced by the glycopeptide bleomycin (Item No. 13877) when administered at a dose of 20 mg/kg per day.2 Formulations containing mogroside IIIE have been used as sweeteners in food products.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tao, L., Cao, F., Xu, G., et al. Mogroside IIIE attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AMPK activation. Phytother. Res. 31(7), 1097-1106 (2017).

    2. Tao, L., Yang, J., Cao, F., et al. Mogroside IIIE, a novel anti-fibrotic compound, reduces pulmonary fibrosis through toll-like receptor 4 pathways. J. Pharmacol. Exp. Ther. 361(2), 268-279 (2017).