A taxane with microtubule-stabilizing and antinociceptive activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Baccatin VI

Item No. 39287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2aR,4S,4aS,5R,6R,9S,11S,12S,12aR,12bS)-2a,3,4,4a,5,6,9,10,12,12a-decahydro-4a,8,13,13-tetramethyl-4,5,6,9,12b-pentaacetate 12-benzoate, 7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-4,5,6,9,11,12,12b-heptol
CAS Number
57672-79-4
Molecular Formula
C37H46O14
Formula Weight
714.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetone: Slightly solubleAcetone: Slightly solubleChloroform: Slightly solubleChloroform: Slightly soluble
SMILES
[H][C@](C[C@@H]1OC(C)=O)(OC2)[C@@]2([C@@]([H])([C@H](OC(C3=CC=CC=C3)=O)[C@@](C[C@@H](C(C)=C4[C@H]5OC(C)=O)OC(C)=O)(O)C4(C)C)[C@]1(C)[C@H]5OC(C)=O)OC(C)=O
InChi Code
InChI=1S/C37H46O14/c1-18-25(46-19(2)38)16-37(44)32(50-33(43)24-13-11-10-12-14-24)30-35(9,26(47-20(3)39)15-27-36(30,17-45-27)51-23(6)42)31(49-22(5)41)29(48-21(4)40)28(18)34(37,7)8/h10-14,25-27,29-32,44H,15-17H2,1-9H3/t25-,26-,27+,29+,30-,31-,32-,35+,36-,37+/m0/s1
InChi Key
UJFKTEIDORFVQS-SKNQRQHZSA-N
Origin
Plant/Taxus baccata L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $109

    Add
    Product Description

    Baccatin VI is a taxane that has been found in T. baccata and has microtubule-stabilizing and antinociceptive activities.1,2 It inhibits cold-induced microtubule depolymerization with half-maximal inhibitory dose (ID50) values of 70 and 100 µM for isolated porcine brain and P. polycephalum microtubules, respectively.1 Baccatin VI decreases p-benzoquinone-induced writhing in mice when administered at a dose of 30 mg/ml.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lataste, H., Senilh, V., Wright, M., et al. Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules. Proc. Natl. Acad. Sci. USA 81(13), 4090-4094 (1984).

    2. Küpeli, E., Erdemoğlu, N., Yeşilada, E., et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J. Ethnopharmacol. 89(2-3), 265-270 (2003).