An inhibitor of the Myc-WDR5 protein-protein interaction
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WDR5-MYC Probe 12

Item No. 39304

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-[[[(1,4-dihydro-6-methyl-4-oxo-1-phenyl-3-pyridazinyl)carbonyl]amino]methyl]-3′,5′-difluoro-[1,1′-biphenyl]-3-sulfonyl fluoride
CAS Number
3033748-20-5
Molecular Formula
C25H18F3N3O4S
Formula Weight
513.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
CC(N1C2=CC=CC=C2)=CC(C(C(NCC3=C(F)C=C(C4=CC(S(F)(=O)=O)=CC=C4)C=C3F)=O)=N1)=O
InChi Code
InChI=1S/C25H18F3N3O4S/c1-15-10-23(32)24(30-31(15)18-7-3-2-4-8-18)25(33)29-14-20-21(26)12-17(13-22(20)27)16-6-5-9-19(11-16)36(28,34)35/h2-13H,14H2,1H3,(H,29,33)
InChi Key
KCMSIHHWMOTDFN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    WDR5-MYC probe 12 is an inhibitor of the protein-protein interaction between the master transcription factor Myc and WD repeat domain 5 (WDR5; IC50 = 0.39 µM).1 It reduces mRNA expression of the Myc and WDR5 co-binding target genes ribosomal protein L17 (RPL17), RPL23, RPL35, and RPL37A in HL-60 cells. WDR5-MYC probe 12 also inhibits the growth of HL-60, NB4, Ramos (RA 1), COR-L279, and NCI H520 cancer cells (GI50s = 4.2-9.4 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ding, J., Liu, L., Chiang, Y.L., et al. Discovery and structure-based design of inhibitors of the WD repeat-containing protein 5 (WDR5)-MYC interaction. J. Med. Chem. 66(12), 8310-8323 (2023).