A cyclic depsipeptide with antibacterial activity
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Griselimycin

Item No. 39306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-N-methyl-L-valyl-(4R)-4-methyl-L-prolyl-N-methyl-L-threonyl-L-leucyl-(4R)-4-methyl-L-prolyl-L-leucyl-N-methyl-L-valyl-L-prolyl-N-methyl-D-leucyl-glycine, (10→3)-lactone
CAS Number
26034-16-2
Synonyms
  • NSC 246122
Molecular Formula
C57H96N10O12
Formula Weight
1113.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CN(C([C@@H]1C[C@@H](C)CN1C([C@H](C(C)C)N(C)C(C)=O)=O)=O)[C@@H]([C@@H](C)OC(CNC([C@H](N(C([C@]2([H])CCCN2C([C@@H](N(C)C([C@@H](NC3=O)CC(C)C)=O)C(C)C)=O)=O)C)CC(C)C)=O)=O)C(N[C@@H](CC(C)C)C(N4[C@@]3([H])C[C@@H](C)C4)=O)=O
InChi Code
InChI=1S/C57H96N10O12/c1-30(2)22-39-52(73)63(17)47(34(9)10)56(77)65-21-19-20-41(65)54(75)62(16)42(24-32(5)6)49(70)58-27-45(69)79-37(13)48(51(72)60-40(23-31(3)4)53(74)66-28-35(11)25-43(66)50(71)59-39)64(18)55(76)44-26-36(12)29-67(44)57(78)46(33(7)8)61(15)38(14)68/h30-37,39-44,46-48H,19-29H2,1-18H3,(H,58,70)(H,59,71)(H,60,72)/t35-,36-,37-,39+,40+,41+,42-,43+,44+,46+,47+,48+/m1/s1
InChi Key
JSNIAKPKPNJUEP-BHYOTPSJSA-N
Origin
Bacterium/Streptomyces muensis
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $414

    Add

    1 mg

    $785

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Griselimycin is a cyclic depsipeptide that has been found in Streptomyces and has antibacterial activity.1,2 It is active against M. tuberculosis strain H37Rv (MICs = 1-1.2 and 6.2 µg/ml in liquid culture and RAW 264.7 macrophages, respectively) but associated with resistance.2 Griselimycin inhibits the protein-protein interaction between the M. smegmatis DNA polymerase sliding clamp, DnaN, and M. smegmatis DNA polymerase, leading to inhibition of DNA replication.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Terlain, B., and Thomas, J.P. Structure of griselimycin, a polypeptide antibiotic extracted from streptomyces cultures. C.R. Acad. Sci. C Chim. 269(24), 1546-1549 (1969).

    2. Kling, A., Lukat, P., Almeida, D.V., et al. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science 348(6239), 1106-1112 (2015).