An Analytical Reference Standard
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Alternative(s)
21449Retigabine
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Retigabine (hydrochloride)

Item No. 39309

Restricted Product (Schedule V)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • D 20443
  • Ezogabine
  • GKE 841
  • GW 582892X
  • WAY-143841
Technical Information
Formal Name
N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamic acid, ethyl ester, dihydrochloride
CAS Number
150812-13-8
Molecular Formula
C16H18FN3O2 • 2HCl
Formula Weight
376.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
λmax
259 nm
SMILES
O=C(OCC)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1.Cl.Cl
InChi Code
InChI=1S/C16H18FN3O2.2ClH/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11;;/h3-9,19H,2,10,18H2,1H3,(H,20,21);2*1H
InChi Key
WSGFOWNASITQHJ-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
V
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Retigabine (Item No. 39309) is an analytical reference standard categorized as a positive allosteric modulator (PAM) of KCNQ2-5 (Kv7.2-7.5) potassium ion channels.1 Formulations containing retigabine have been used in the treatment of partial epilepsies. Retigabine is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gunthrope, M.J., Large, C.H., and Sankar, R. The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy. Epilepsia 53(3), 412-424 (2012).