An ionizable cationic lipid
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C3-K2-E14

Item No. 39323

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3'-(propylazanediyl)bis(N-(2-(bis(2-hydroxytetradecyl)amino)ethyl)propanamide)
CAS Number
2933215-86-0
Molecular Formula
C69H141N5O6
Formula Weight
1136.9
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
CCCN(CCC(NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)CCC(NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O
InChi Code
InChI=1S/C69H141N5O6/c1-6-11-15-19-23-27-31-35-39-43-47-64(75)60-73(61-65(76)48-44-40-36-32-28-24-20-16-12-7-2)58-53-70-68(79)51-56-72(55-10-5)57-52-69(80)71-54-59-74(62-66(77)49-45-41-37-33-29-25-21-17-13-8-3)63-67(78)50-46-42-38-34-30-26-22-18-14-9-4/h64-67,75-78H,6-63H2,1-5H3,(H,70,79)(H,71,80)
InChi Key
ZNFXNNRQRPINEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $46

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    C3-K2-E14 is an ionizable cationic lipid.1,2 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, and long intergenic noncoding RNA (lncRNA) in vitro and in vivo. LNPs containing C3-K2-E14 and encapsulating siRNA targeting the gene encoding colony-stimulating factor 1 (CSF1) reduce the percentage of circulating monocytes with high expression of lymphocyte antigen 6 complex, locus protein C (Ly6Chi) and increase the percentage of circulating monocytes with intermediate Ly6C expression (Ly6Cint) in mice.1 LNPs containing C3-K2-E14 and encapsulating gastric adenocarcinoma predictive long intergenic noncoding RNA (GAPLINC) reduce LPS-induced NF-κB activation in a secreted alkaline phosphatase (SEAP) assay using RAW 264.7 reporter cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Manning, A.M., Tilstra, G., Khan, A.B., et al. Ionizable lipid with supramolecular chemistry features for RNA delivery in vivo. Small 19(41), e2302917 (2023).

    2. Pang, J., Lau, Y.M.A., Mahbub, F., et al. Human and mouse long noncoding RNAs reengineered for exogenous delivery reduce LPS-induced inflammation in human macrophages and mice. Sci. Signal 19(928), eadx2924 (2026).