A 15-LO-2/PEBP1 and ferroptosis inhibitor
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FerroLOXIN-1

Item No. 39325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenyl-1H-imidazol-2-amine
CAS Number
2773428-48-9
Molecular Formula
C23H16F5N3
Formula Weight
429.4
Purity
≥90%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
FC1=CC=CC(N2C(NCC(C=C3)=CC(F)=C3C(F)(F)F)=NC(C4=CC=CC=C4)=C2)=C1
InChi Code
InChI=1S/C23H16F5N3/c24-17-7-4-8-18(12-17)31-14-21(16-5-2-1-3-6-16)30-22(31)29-13-15-9-10-19(20(25)11-15)23(26,27)28/h1-12,14H,13H2,(H,29,30)
InChi Key
TZTVXYFOBQIIBL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $152

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    10 mg

    $288

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    Product Description

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.1 It selectively inhibits the peroxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (Item No. 25871) by the 15-LO-2/PEBP1 complex over 15-LO-2 alone in cell-free assays when used at a concentration of 0.25 µM. FerroLOXIN-1 inhibits RSL3-induced ferroptosis in primary human bronchial epithelial cells (IC50 = 84 nM). It increases survival in a mouse model of total body irradiation when administered at a dose of 25 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dar, H.H., Mikulska-Ruminska, K., Tyurina, Y.Y., et al. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediator. PNAS 120(25), e2218896120 (2023).