An NLRP3 inflammasome inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

D359-0396

Item No. 39386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,9-dihydro-7,9-dimethyl-6-[4-(1-methylethyl)phenyl]-pyrimido[4′,5′:3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,7H)-dione
CAS Number
1031977-31-7
Molecular Formula
C24H24N4O2
Formula Weight
400.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CN(C1=C2N(C=C1C3=O)C4=C(C=CC=C4)NC2C(C=C5)=CC=C5C(C)C)C(N3C)=O
InChi Code
InChI=1S/C24H24N4O2/c1-14(2)15-9-11-16(12-10-15)20-22-21-17(23(29)27(4)24(30)26(21)3)13-28(22)19-8-6-5-7-18(19)25-20/h5-14,20,25H,1-4H3
InChi Key
NYQHEGVGLCCWEM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $199

    Add

    10 mg

    $318

    Add

    25 mg

    $597

    Add

    50 mg

    $896

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    D359-0396 is an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome.1 It is selective for NLRP3 over the absent in melanoma 2 (AIM2) and NLR family CARD domain-containing protein 4 (NLRC4) inflammasomes at 100 µM. D359-0396 inhibits pyroptosis induced by ATP (Item Nos. 14498 | 40182) or nigericin (Item No. 11437) in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs). It also inhibits LPS- and ATP-induced NLRP3 self-oligomerization and apoptosis-associated speck-like protein (ASC) oligomerization in vitro at 20 µM. D359-0396 decreases disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) and increases survival in a mouse model of septic shock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Z., Ji, S., Wu, C., et al. Identification of D359-0396 as a novel inhibitor of the activation of NLRP3 inflammasome. Neurochem. Int. 169:105565, (2023).