A dynamin inhibitor
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Sulfonadyn-47

Item No. 39402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-N-(3-((3-(4-bromophenyl)allyl)amino)propyl)naphthalene-1-sulfonamide
Molecular Formula
C22H23BrN2O2S
Formula Weight
459.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
221, 261 nm
SMILES
BrC1=CC=C(/C=C/CNCCCNS(=O)(C2=C(C=CC=C3)C3=CC=C2)=O)C=C1
InChi Code
InChI=1S/C22H23BrN2O2S/c23-20-13-11-18(12-14-20)6-4-15-24-16-5-17-25-28(26,27)22-10-3-8-19-7-1-2-9-21(19)22/h1-4,6-14,24-25H,5,15-17H2/b6-4+
InChi Key
ZYCDTZNHEUVRAI-GQCTYLIASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $32

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    1 mg

    $58

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    5 mg

    $256

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    10 mg

    $479

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    Product Description

    Sulfonadyn-47 is a dynamin inhibitor.1 It inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM). Sulfonadyn-47 inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64, a marker of synaptic vesicle endocytosis (SVE), in isolated rat brain synaptosomes (IC50 = 12.3 µM). In vivo, sulfonadyn-47 (30 and 60 mg/kg) has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Odell, L.R., Jones, N.C., Chau, N., et al. The sulfonadyns: A class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Med. Chem. 14(8), 1492-1511 (2023).