A BCRP inhibitor
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33-BCRP Inhibitor

Item No. 39403

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-azidophenyl)-2-(4-pyridinyl)-4-quinazolinamine
CAS Number
2953730-35-1
Synonyms
  • 33-Breast Cancer Resistance Protein Inhibitor
Molecular Formula
C19H13N7
Formula Weight
339.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
λmax
249 nm
SMILES
[N-]=[N+]=NC(C=C1)=CC=C1NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42
InChi Code
InChI=1S/C19H13N7/c20-26-25-15-7-5-14(6-8-15)22-19-16-3-1-2-4-17(16)23-18(24-19)13-9-11-21-12-10-13/h1-12H,(H,22,23,24)
InChi Key
RKCAPAXYHIXQLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $44

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    5 mg

    $198

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    10 mg

    $351

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    Cayman Chemical
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    Product Description

    33-BCRP inhibitor is an inhibitor of breast cancer resistance protein (BCRP).1 It sensitizes mitoxantrone-resistant H460/MX20 lung cancer cells to mitoxantrone-induced cell death alone and in combination with UV radiation. 33-BCRP inhibitor also sensitizes KB-C2 epidermal carcinoma cells overexpressing P-glycoprotein (P-gp), also known as multidrug resistance protein (MDR), to colchicine-induced cell death. It increases intracellular accumulation of mitoxantrone (Item No. 14842) in H460/MX20 cells when used at a concentration of 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cai, C.-Y., Teng, Q.-X., Murakami, M., et al. Design, synthesis and biological evaluation of quinazolinamine derivatives as breast cancer resistance protein and p-glycoprotein inhibitors with improved metabolic stability. Biomolecules 13(2), 253 (2023).