A cyanotriazole antiparasitic
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CT3

Item No. 39416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[5-[5-fluoro-2-(trifluoromethyl)-3-pyridinyl]-1,3-dihydro-2H-isoindol-2-yl]-2-oxoethyl]-1H-1,2,4-triazole-3-carbonitrile
CAS Number
2403729-27-9
Synonyms
  • Cyanotriazole 3
Molecular Formula
C19H12F4N6O
Formula Weight
416.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: Slightly soluble
SMILES
N#CC1=NN(CC(N2CC3=C(C2)C=C(C4=CC(F)=CN=C4C(F)(F)F)C=C3)=O)C=N1
InChi Code
InChI=1S/C19H12F4N6O/c20-14-4-15(18(25-6-14)19(21,22)23)11-1-2-12-7-28(8-13(12)3-11)17(30)9-29-10-26-16(5-24)27-29/h1-4,6,10H,7-9H2
InChi Key
JDTWUDDOSHJEIZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $31

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    1 mg

    $55

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    5 mg

    $131

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    Cayman Chemical
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    Product Description

    CT3 is a cyanotriazole antiparasitic.1 It is active against T. b. brucei, T. b. gambiense, T. b. rhodesiense, T. cruzi, and L. donovani (EC50s = 180, 31, 57, 78, and 134 nM, respectively). CT3 (4 µM) inhibits nuclear, but not kinetoplastid, DNA replication in the bloodstream form of T. b. brucei. It inhibits T. cruzi topoisomerase II but not human topoisomerase II-α. CT3 (30 mg/kg per day for five days) eradicates T. cruzi in a mouse model of Chagas disease. It also eradicates the T. b. brucei strain STIB975 at stage I and stage II in a mouse model of African trypanosomiasis when administered at a dose of 10 mg/kg for four or seven days, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rao, S.P.S., Gould, M.K., Noeske, J., et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science 380(6652), 1349-1356 (2023).