A Nurr1 receptor agonist
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4A7C-301-Nurr1 Agonist

Item No. 39453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-(4,6-bis(4-ethylpiperazin-1-yl)pyrimidin-2-yl)-N2-(7-chloroquinolin-4-yl)ethane-1,2-diamine
Synonyms
  • 4A7C-301-Nuclear Receptor-Related 1
Molecular Formula
C27H38ClN9
Formula Weight
524.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
λmax
221 nm
SMILES
CCN1CCN(C2=CC(N3CCN(CC)CC3)=NC(NCCNC4=C(C=CC(Cl)=C5)C5=NC=C4)=N2)CC1
InChi Code
InChI=1S/C27H38ClN9/c1-3-34-11-15-36(16-12-34)25-20-26(37-17-13-35(4-2)14-18-37)33-27(32-25)31-10-9-30-23-7-8-29-24-19-21(28)5-6-22(23)24/h5-8,19-20H,3-4,9-18H2,1-2H3,(H,29,30)(H,31,32,33)
InChi Key
WLTYONMUIIBIKQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $29

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    1 mg

    $43

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    5 mg

    $184

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    Product Description

    4A7C-301-Nurr1 agonist is an agonist of nuclear receptor-related 1 (Nurr1).1 It binds to the Nurr1 ligand-binding domain (LBD; IC50 = 48.22 nM) and increases transcriptional activity of Nurr1-LBD and full-length Nurr1 in reporter assays using SK-N-BE(2)C human neuroblastoma cells (EC50s = 6.53 and 50-70 µM, respectively). 4A7C-301-Nurr1 agonist (5 mg/kg per day) decreases dopaminergic cell death in the striatum and substantia nigra pars compacta, as well as reduces motor and olfactory deficits, without inducing dyskinesia-like behaviors in mouse models of Parkinson’s disease induced by the neurotoxin MPTP or by overexpression of α-synuclein.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, W., Tripathi, M., Kim, C., et al. An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models. Nat Commun 14(1), 4283 (2023).