An antiparasitic agent
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NPD-2975

Item No. 39466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-fluorophenyl)-1,6-dihydro-3-(1-methylethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS Number
3032452-65-3
Molecular Formula
C14H13FN4O
Formula Weight
272.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
λmax
230, 292 nm
SMILES
FC1=CC=C(C2=NC(C(C(C)C)=NN3)=C3C(N2)=O)C=C1
InChi Code
InChI=1S/C14H13FN4O/c1-7(2)10-11-12(19-18-10)14(20)17-13(16-11)8-3-5-9(15)6-4-8/h3-7H,1-2H3,(H,18,19)(H,16,17,20)
InChi Key
OJEVXJSJYBCDSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $294

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    10 mg

    $556

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    Cayman Chemical
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    Product Description

    NPD-2975 is an antiparasitic agent.1 It reduces the proliferation of T. brucei (IC50 = 63.1 nM) but not T. cruzi, L. infantum, P. falciparum, or human MRC-5 fibroblasts (IC50s = >6,000 nM for all). In vivo, NPD-2975 (50 mg/kg twice per day) reduces peripheral blood parasite levels below detection limits and increases survival in a mouse model of T. brucei infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zheng, Y., van den Kerkhof, M., van der Meer, T., et al. Discovery of 5-phenylpyrazolopyrimidinone analogs as potent antitrypanosomal agents with in vivo efficacy. J. Med. Chem. 66(15), 10252-10264 (2023).