An HDAC6 inhibitor
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J27644

Item No. 39469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(8-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolinyl)methyl]-N-hydroxy-benzamide
CAS Number
3033032-03-7
Molecular Formula
C16H12ClN3O4
Formula Weight
345.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C1=CC=CC(Cl)=C1N2CC3=CC=C(C(NO)=O)C=C3)NC2=O
InChi Code
InChI=1S/C16H12ClN3O4/c17-12-3-1-2-11-13(12)20(16(23)18-15(11)22)8-9-4-6-10(7-5-9)14(21)19-24/h1-7,24H,8H2,(H,19,21)(H,18,22,23)
InChi Key
OWMZGLVMABQUAQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $280

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    5 mg

    $1,118

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    Product Description

    J27644 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 10 nM).1 It is selective for HDAC6 over HDAC1-5 (IC50s = 211-516 nM) and HDAC7, -8, -9, and -11 (IC50s = 137-812 nM). J27644 (10 µM) reduces the level of proteins involved in fibrosis, including collagen 1A1, α-smooth muscle actin (α-SMA), and fibronectin, in human pulmonary fibroblasts in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, W.-C., Yeh, T.-Y., Ye, C.-H., et al. Discovery of HDAC6, HDAC8, and 6/8 inhibitors and development of cell-based drug screening models for the treatment of TGF-β-induced idiopathic pulmonary fibrosis. J. Med. Chem. 66(15), 10528-10557 (2023).