A positive allosteric modulator of 5-HT2A and 5-HT2C receptors
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JPC0323

Item No. 39470

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-9Z-octadecenamide
CAS Number
5972-45-2
Molecular Formula
C22H43NO4
Formula Weight
385.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O=C(NC(CO)(CO)CO)CCCCCCC/C=C\CCCCCCCC
InChi Code
InChI=1S/C22H43NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(27)23-22(18-24,19-25)20-26/h9-10,24-26H,2-8,11-20H2,1H3,(H,23,27)/b10-9-
InChi Key
JLFKELVBPUSMGW-KTKRTIGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $182

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    5 mg

    $681

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    10 mg

    $1,089

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    Product Description

    JPC0323 is a positive allosteric modulator of the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C.1 It is selective for these receptors over a panel of 21 receptors and transporters at 10 µM. JPC0323 (1 nM) enhances 5-HT-induced calcium release in CHO cells expressing recombinant human 5-HT2A or 5-HT2C. In vivo, JPC0323 (30 mg/kg) reduces spontaneous locomotor activity in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Garcia, E.J., Merritt, C.R., et al. Discovery of novel oleamide analogues as brain-penetrant positive allosteric serotonin 5-HT2C receptor and dual 5-HT2C/5-HT2A receptor modulators. J. Med. Chem. 66(14), 9992-10009 (2023).