A synthetic corticosteroid and prodrug from of betamethasone
Related Products
Active Metabolite(s)
20363Betamethasone
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Betamethasone Dipropionate

Item No. 39499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β-hydroxy-16β-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
5593-20-4
Synonyms
  • Betamethasone 17,21-Dipropionate
  • β-Methasone Dipropionate
  • SCH 11460
Molecular Formula
C28H37FO7
Formula Weight
504.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
C[C@@]12[C@@](OC(CC)=O)(C(COC(CC)=O)=O)[C@@H](C)C[C@@]1([H])[C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F
InChi Code
InChI=1S/C28H37FO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
InChi Key
CIWBQSYVNNPZIQ-XYWKZLDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $43

    Add

    100 mg

    $77

    Add

    250 mg

    $161

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Betamethasone dipropionate is a synthetic corticosteroid and prodrug form of betamethasone (Item No. 20363).1,2 It binds to the glucocorticoid receptor (IC50 = 5.25 nM).1 Betamethasone dipropionate decreases the number of circulating eosinophils in dogs and reduces croton oil-induced exudate formation in a granuloma pouch assay in rats.3 Formulations containing betamethasone dipropionate have been used in the treatment of dermatoses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ueno, H., Maruyama, A., Miyake, M., et al. Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 α-esters containing a functional group. J. Med. Chem. 34(8), 2468-2473 (1991).

    2. Li, L., Zhang, M., P., M., et al. Development of a simple method for simultaneous determination of tazarotene and betamethasone dipropionate and their metabolites using LC-MS method and its application to dermatopharmacokinetic study. Biomed. Chromatogr. 33(8), e4557 (2019).

    3. Collins, E.J., Aschenbrenner, J., and Nakahama, M. Biologic action of betamethasone 17,21-dipropionate in rat and dog. Steroids 20(5), 543-554 (1972).