An ionizable cationic lipid
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Lipid C3

Item No. 39516

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-[[3-[4-[2-[[3-[bis(2-hydroxyhexadecyl)amino]-2-ethoxypropyl](2-hydroxyhexadecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis-2-hexadecanol
CAS Number
2639634-93-6
Synonyms
  • C16-6
Molecular Formula
C96H197N5O7
Formula Weight
1533.6
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CCOC(CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC)CN(CC1)CCN1CCN(CC(O)CCCCCCCCCCCCCC)CC(OCC)CN(CC(O)CCCCCCCCCCCCCC)CC(O)CCCCCCCCCCCCCC
InChi Code
InChI=1S/C96H197N5O7/c1-8-15-20-25-30-35-40-45-50-55-60-65-70-90(102)81-99(87-96(108-14-7)89-101(84-93(105)73-68-63-58-53-48-43-38-33-28-23-18-11-4)85-94(106)74-69-64-59-54-49-44-39-34-29-24-19-12-5)80-77-97-75-78-98(79-76-97)86-95(107-13-6)88-100(82-91(103)71-66-61-56-51-46-41-36-31-26-21-16-9-2)83-92(104)72-67-62-57-52-47-42-37-32-27-22-17-10-3/h90-96,102-106H,8-89H2,1-7H3
InChi Key
YBMHQKBQHUBBHK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $94

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    Lipid C3 is an ionizable cationic lipid (pKa = 5.05-5.671).1,2 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating mRNA encoding α-L-iduronidase (Idua) to neonates increase midbrain and hippocampal α-L-iduronidase enzyme activity and decrease forebrain, midbrain, and hippocampal glycosaminoglycan levels in an Idua-W392X mouse model of the lysosomal storage disorder mucopolysaccharidosis type I, also known as Hurler syndrome. Intracerebroventricular administration of LNPs containing lipid C3 and encapsulating an mRNA reporter to fetal macaques in utero increase brain GFP expression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Palanki, R., Bose, S.K., Dave, A., et al. Ionizable lipid nanoparticles for therapeutic base editing of congenital brain disease. ACS Nano 17(14), 13594-13610 (2023).

    2. Billingsley, M.M., Singh, N., Ravikumar, P., et al. Ionizable lipid nanoparticle-mediated mRNA delivery for human car T cell engineering. Nano Lett. 20(3), 1578-1589 (2020).