A SARM1 inhibitor
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DSRM-3716

Item No. 39517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-iodo-isoquinoline
CAS Number
58142-99-7
Molecular Formula
C9H6IN
Formula Weight
255.1
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
IC1=CC=CC2=C1C=CN=C2
InChi Code
InChI=1S/C9H6IN/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-6H
InChi Key
CUILFTFMBBGSFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $50

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    5 g

    $235

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    Product Description

    DSRM-3716 is an inhibitor of the axonal degeneration mediator and NADase sterile alpha and TIR motif containing 1 (SARM1; IC50 = 75 nM).1 It decreases levels of cyclic ADP ribose (cADPR) and increases NAD+ levels in axotomized primary mouse dorsal root ganglia (DRG) axons when used at concentrations ranging from 1.1 to 30 µM. DSRM-3716 (0.1-10 µM) prevents axonal degeneration in primary wild-type but not Sarm1-/- axotomized DRG axons.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Herxheimer, H., and Stresemann, E. The effect of some new antihistamines on the anaphylactic microshock of the guinea-pig. Br. J. Pharmacol. Chemother. 21(3), 414-418 (1963).