A uPA inhibitor
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BC-11 (hydrobromide)

Item No. 39522

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
carbamimidothioic acid, (4-boronophenyl)methyl ester, monohydrobromide
CAS Number
443776-49-6
Synonyms
  • uPA Inhibitor BC-11
  • Urokinase-type Plasminogen Activator Inhibitor BC-11
Molecular Formula
C8H11BN2O2S • HBr
Formula Weight
291.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 20 mg/mlWater: 10 mg/ml
SMILES
NC(SCC1=CC=C(B(O)O)C=C1)=N.Br
InChi Code
InChI=1S/C8H11BN2O2S.BrH/c10-8(11)14-5-6-1-3-7(4-2-6)9(12)13;/h1-4,12-13H,5H2,(H3,10,11);1H
InChi Key
PAFZAMOVHIRQOD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

    $152

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    25 mg

    $359

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    Cayman Chemical
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    Product Description

    BC-11 is an inhibitor of the serine protease urokinase-type plasminogen activator (uPA).1 It reduces cell viability of MDA-MB-231 cells (EC50 = 117 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Longo, A., Librizzi, M., Chuckowree, I.S., et al. Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells. Molecules 20(6), 9879-9889 (2015).