An Mcl-1 inhibitor
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VU0661013

Item No. 39524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-1H-indole-5-carboxylic acid
CAS Number
2131184-57-9
Molecular Formula
C39H39Cl2N5O4
Formula Weight
712.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
C[C@H]1N2C3=C(C4=C(C)N(C)N=C4C)C(Cl)=CC=C3C(CCCOC5=CC(C)=C(C(C)=C5)Cl)=C2C(N(C(C6=C7)=CN(C)C6=CC=C7C(O)=O)C1)=O
InChi Code
InChI=1S/C39H39Cl2N5O4/c1-20-15-26(16-21(2)35(20)41)50-14-8-9-27-28-11-12-30(40)34(33-23(4)42-44(7)24(33)5)36(28)46-22(3)18-45(38(47)37(27)46)32-19-43(6)31-13-10-25(39(48)49)17-29(31)32/h10-13,15-17,19,22H,8-9,14,18H2,1-7H3,(H,48,49)/t22-/m1/s1
InChi Key
BSAYHBZFNXDOIJ-JOCHJYFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    10 mg

    $872

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    Cayman Chemical
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    Product Description

    VU0661013 is an inhibitor of myeloid cell leukemia-1 (Mcl-1; Ki = 97 pM).1 It is selective for Mcl-1 over Bcl-xL and Bcl-2 (Kis = >40 and 0.73 µM, respectively). VU0661013 inhibits cell growth in a panel of acute myeloid leukemia (AML) cell lines (GI50s = 0.16-7.62 µM). It decreases blood, bone marrow, and spleen leukemic burden, reduces splenomegaly, and increases survival in a MV4-11 disseminated AML mouse xenograft model when administered at a dose of 75 mg/kg. VU0661013 also selectively inhibits glutathione peroxidase 4 (GPX4; IC50 = 8.4 µM) over GPX1, GPX2, glutathione reductase (GR), and thioredoxin reductase 1 (TrxR1).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ramsey, H.E., Fischer, M.A., Lee, T., et al. A novel MCL1 inhibitor combined with venetoclax rescues venetoclax-resistant acute myelogenous leukemia. Cancer Discov. 8(12), 1566-1581 (2018).

    2. Cheff, D.M., Cheng, Q., Guo, H., et al. Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4. Redox Biol. 63:102719, (2023).