An inhibitor of PCNA
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AOH1996

Item No. 39526

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[[2-(3-methoxyphenoxy)phenyl]amino]-2-oxoethyl]-1-naphthalenecarboxamide
CAS Number
2089314-64-5
Molecular Formula
C26H22N2O4
Formula Weight
426.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: SolubleMethanol: Soluble
λmax
222 nm
SMILES
O=C(C1=CC=CC2=C1C=CC=C2)NCC(NC3=C(C=CC=C3)OC4=CC=CC(OC)=C4)=O
InChi Code
InChI=1S/C26H22N2O4/c1-31-19-10-7-11-20(16-19)32-24-15-5-4-14-23(24)28-25(29)17-27-26(30)22-13-6-9-18-8-2-3-12-21(18)22/h2-16H,17H2,1H3,(H,27,30)(H,28,29)
InChi Key
HDMONPHKMIZXDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    AOH1996 is an inhibitor of proliferating cell nuclear antigen (PCNA).1 It binds to PCNA in a thermal shift assay. AOH1996 (500 nM) induces apoptosis in SK-N-DZ neuroblastoma cells but not 7SMOO32 normal neural crest stem cells. It induces DNA damage in SK-N-AS neuroblastoma cells expressing wild-type DNA-directed RNA polymerase II subunit RPB1 but not in SK-N-AS cells expressing RPB1Y418A. AOH1996 (40 mg/kg) decreases tumor volume in SK-N-BE(2)-C neuroblastoma, MDA-MB-468 breast cancer, and NCI H82 small cell lung cancer mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, L., Li, M., Li, C.M., et al. Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem. Biol. 30, 1-13 (2023).