A muscarinic DREADD agonist
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Isomer(s)
39531JHU37160
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JHU37152

Item No. 39532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine
CAS Number
2369979-67-7
Molecular Formula
C19H20ClFN4
Formula Weight
358.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
FC1=CC=CC2=C1C(N3CCN(CC3)CC)=NC4=CC(Cl)=CC=C4N2
InChi Code
InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-18-14(21)4-3-5-16(18)22-15-7-6-13(20)12-17(15)23-19/h3-7,12,22H,2,8-11H2,1H3
InChi Key
NZMZJNNWMSYDNX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $158

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    25 mg

    $372

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    Product Description

    JHU37152 is an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (mAChRs).1 It binds to hM3Dq and hM4Di receptors (Kis = 1.8 and 8.7 nM, respectively) and induces Gαo1 activation in HEK293 cells expressing hM3Dq or hM4Di (EC50s = 5 and 0.5 nM, respectively). In vivo, JHU37152 (1 mg/kg) inhibits locomotor activity in D1-hM3Dq and D1-hM4Di transgenic mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonaventura, J., Eldridge, M.A.G., Hu, F., et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat. Commun. 10(1), 4627 (2019).