An inhibitor of PARP14 MD2
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GeA-69

Item No. 39533

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(9H-carbazol-1-yl)phenyl]-acetamide
CAS Number
2143475-98-1
Molecular Formula
C20H16N2O
Formula Weight
300.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CC(NC1=C(C2=C3NC4=C(C=CC=C4)C3=CC=C2)C=CC=C1)=O
InChi Code
InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23)
InChi Key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $120

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    10 mg

    $169

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    25 mg

    $352

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    Cayman Chemical
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    Product Description

    GeA-69 is an inhibitor of poly(ADP-ribose) polymerase 14 macrodomain 2 (PARP14 MD2).1 It binds to PARP14 MD2 (Kd = 860 nM) and inhibits PARP14 MD2 relocalization to the sites of DNA damage in U2OS cells when used at a concentration of 50 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schuller, M., Riedel, K., Gibbs-Seymour, I., et al. Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymerase 14. ACS Chem. Biol. 12(11), 2866-2874 (2017).