A TLR3, TLR8, and TLR9 receptor agonist
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CU-CPT17e

Item No. 39534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′,3′,5′,6′-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-spiro[2H-1-benzopyran-2,4′-[4H]pyran]
CAS Number
2109805-75-4
Molecular Formula
C27H24N2O8
Formula Weight
504.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: Slightly soluble
SMILES
O=[N+](C1=CC=C(COC2=CC(C=CC3(CCOCC3)O4)=C4C=C2OCC5=CC=C([N+]([O-])=O)C=C5)C=C1)[O-]
InChi Code
InChI=1S/C27H24N2O8/c30-28(31)22-5-1-19(2-6-22)17-35-25-15-21-9-10-27(11-13-34-14-12-27)37-24(21)16-26(25)36-18-20-3-7-23(8-4-20)29(32)33/h1-10,15-16H,11-14,17-18H2
InChi Key
LHTNFHWDTHQECR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $644

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    25 mg

    $990

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    Product Description

    CU-CPT17e is an agonist of toll-like receptor 3 (TLR3), TLR8, and TLR9.1 It selectively induces NF-κB activation in HEK293 cells expressing recombinant human TLR3, TLR8, or TLR9 (EC50s = 4.8, 13.45, and 5.66 µM, respectively) over HEK293 cells expressing recombinant human TLR2, TLR4, TLR5, or TLR7 (EC50s = >100 µM for all). CU-CPT17e (5-40 µM) induces TNF-α, IL-6, and IL-8 production in THP-1 cells. It also inhibits the growth of HeLa cells (IC50 = 2.71 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, L., Dewan, V., and Yin, H. Discovery of small molecules as multi-toll-like receptor agonists with proinflammatory and anticancer activities. J. Med. Chem. 60(12), 5029-5044 (2017).