A FUC8 inhibitor
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FDW028

Item No. 39543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(4-ethylphenyl)methyl]amino]-5-[[(phenylmethyl)amino]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
CAS Number
2768426-49-7
Molecular Formula
C22H24N6O
Formula Weight
388.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31
InChi Code
InChI=1S/C22H24N6O/c1-2-16-8-10-18(11-9-16)14-24-21-26-22-25-19(12-20(29)28(22)27-21)15-23-13-17-6-4-3-5-7-17/h3-12,23,29H,2,13-15H2,1H3,(H,24,27)
InChi Key
LJEVZCFIZASGBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $248

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    25 mg

    $482

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    50 mg

    $757

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    Cayman Chemical
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    Product Description

    FDW028 is an inhibitor of fucosyltransferase 8 (FUC8).1 It binds to FUC8 (Kd = 5.486 µM) and inhibits core fucosylation in HCT-8 and SW480 colorectal cancer (CRC) cells. FDW028 (50 µM) induces degradation of B7-H3, also known as CD276, via chaperone-mediated autophagy (CMA) in the same cells. In vivo, FDW028 (10 and 20 mg/kg) reduces tumor volume and increases survival in an SW480 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, M., Zhang, Z., Chen, M., et al. FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer. Cell Death Dis. 14(8), 495 (2023).