An internal standard for the quantification of betamethasone
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Unlabeled Version(s)
20363Betamethasone
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Betamethasone-d5

Item No. 39560

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione-4,6,11,12,12-d5
CAS Number
2244574-92-1
Synonyms
  • β-Methasone-d5
Molecular Formula
C22H24D5FO5
Formula Weight
397.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C1C=C[C@@]2(C)C(C([2H])C[C@]3([H])[C@]2(F)[C@](O)([2H])C([2H])([2H])[C@@]4(C)[C@@]3([H])C[C@H](C)[C@]4(O)C(CO)=O)=C1[2H]
InChi Code
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1/i4D,9D,10D2,17D/t4?,12-,15-,16-,17-,19-,20-,21-,22-
InChi Key
UREBDLICKHMUKA-RXBGCOSMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $721

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    Product Description

    Betamethasone-d5 is intended for use as an internal standard for the quantification of betamethasone (Item No. 20363) by GC- or LC-MS. Betamethasone is a synthetic corticosteroid.1 In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-α levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.2 It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).3 Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Corbel, M., Lagente, V., Théret, N., et al. Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide. Pulm. Pharmacol. Ther. 12(3), 165-171 (1999).

    2. van der Merwe, J., van der Veeken, L., Inversetti, A., et al. Neurocognitive sequelae of antenatal corticosteroids in a late preterm rabbit model. Am. J. Obstet. Gynecol. 226(6), 850.e851-850.e821 (2022).

    3. Galaz, J., Romero, R., Arenas-Hernandez, M., et al. Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: A murine study. J. Perinat. Med. 49(7), 897-906 (2021).