An inhibitor of KCa2.3 and KCa3.1
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RA-2

Item No. 39567

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-fluoro-4-hydroxy-1,1′-[1,3-phenylenebis(methylene)] ester, benzoic acid
CAS Number
1867107-62-7
Molecular Formula
C22H16F2O6
Formula Weight
414.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlEthanol: 15 mg/ml
SMILES
O=C(C1=CC=C(C(F)=C1)O)OCC2=CC=CC(COC(C3=CC=C(C(F)=C3)O)=O)=C2
InChi Code
InChI=1S/C22H16F2O6/c23-17-9-15(4-6-19(17)25)21(27)29-11-13-2-1-3-14(8-13)12-30-22(28)16-5-7-20(26)18(24)10-16/h1-10,25-26H,11-12H2
InChi Key
XOZKRECPKXTNAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $153

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    Product Description

    RA-2 is an inhibitor of small-conductance calcium-activated potassium channel 2.3 (KCa2.3/SK3) and intermediate-conductance calcium-activated potassium channel 3.1 (KCa3.1/IK1) (IC50s = 2 and 17 nM, respectively).1 It is selective for these channels over KCa1.1/BK1, voltage-gated potassium channel 1.2 (Kv1.2), Kv1.3, Kv7.4, human-ether-a-go-go (hERG), also known as Kv11.1, and the inward-rectifier potassium channel (Kir), but also inhibits KCa2.1 and KCa2.2 by 96 and 90%, respectively, at 1 µM. RA-2 (1 µM) inhibits bradykinin-induced relaxation of porcine coronary artery rings precontracted with the TP receptor agonist U-46619 (Item No. 16450). It decreases heart rate, but not mean arterial blood pressure, in mice when administered at a dose of 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oliván-Viguera, A., Valero, M.S., Coleman, N., et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol. Pharmacol. 87(2), 338-348 (2018).