A degrader of cyclin K
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NCT-02

Item No. 39568

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
CAS Number
790245-61-3
Molecular Formula
C17H16N2O2S
Formula Weight
312.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
O=C(NC1=NC=C(C)S1)CC2=COC3=C2C=C(CCC4)C4=C3
InChi Code
InChI=1S/C17H16N2O2S/c1-10-8-18-17(22-10)19-16(20)7-13-9-21-15-6-12-4-2-3-11(12)5-14(13)15/h5-6,8-9H,2-4,7H2,1H3,(H,18,19,20)
InChi Key
IELCYEUTXLYDOV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    NCT-02 is a degrader of cyclin K.1 It reduces the levels of cyclin K in patient-derived colorectal cancer (CRC) cells in a concentration-dependent manner. NCT-02 inhibits cancer cell proliferation in CRC tissue samples isolated from the colon (IC50s = 0.9-20.6 µM), as well as from hepatic, lung, and rectal metastases (IC50s = 0.5-11.8, 1, and 1.4-38.4 µM, respectively). It decreases the levels of Ataxia-telangiectasia mutated kinase (ATM) and RAD51 in patient-derived CRC tissues when used at concentrations 0.7 and 0.5 µM, respectively. NCT-02 (3 µM) reduces the number of spheroids formed and induces poly(ADP-ribose) polymerase (PARP) cleavage in patient-derived CRC spheroid cultures.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dieter, S.M., Siegl, C., Codó, P.L., et al. Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 36(3), 109394 (2021).