An inhibitor of Wnt signaling
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WIC1

Item No. 39574

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide
CAS Number
943083-58-7
Synonyms
  • Wnt Inhibitor Compound 1
Molecular Formula
C22H23N3O3
Formula Weight
377.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(NC1=CC=C(N2CCN(CC2)CC)C=C1)C3=CC4=C(OC3=O)C=CC=C4
InChi Code
InChI=1S/C22H23N3O3/c1-2-24-11-13-25(14-12-24)18-9-7-17(8-10-18)23-21(26)19-15-16-5-3-4-6-20(16)28-22(19)27/h3-10,15H,2,11-14H2,1H3,(H,23,26)
InChi Key
YQXKWSNLAVFZJL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $40

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    10 mg

    $76

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    25 mg

    $179

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    50 mg

    $335

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    Product Description

    WIC1 is an inhibitor of Wnt signaling.1 It inhibits Wnt signaling induced by the glycogen synthase kinase 3β (GSK3β) inhibitor CHIR99021 (Item No. 13122) in a reporter assay using BEAS-2B cells when used at a concentration of 100 nM. WIC1 (1 µM) induces differentiation of, and decreases CHIR99021-induced hyperproliferation of, and nuclear phosphorylation of β-catenin in, isolated mouse airway basal stem cells (ABSCs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aros, C.J., Paul, M.K., Pantoja, C.J., et al. High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 30(7), 2055-2064.e2055 (2020).