An ionizable cationic lipid
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A1-28

Item No. 39590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-((4-methyl-11-oxo-12-oxa-15,16-dithia-4,8-diazaoctacosyl)azanediyl)dipropionate
CAS Number
3055572-07-8
Synonyms
  • AMAP-O16B
Molecular Formula
C58H115N3O6S6
Formula Weight
1142.9
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
CCCCCCCCCCCCSSCCOC(CCNCCCN(C)CCCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O)=O
InChi Code
InChI=1S/C58H115N3O6S6/c1-5-8-11-14-17-20-23-26-29-32-50-68-71-53-47-65-56(62)37-41-59-40-35-42-60(4)43-36-44-61(45-38-57(63)66-48-54-72-69-51-33-30-27-24-21-18-15-12-9-6-2)46-39-58(64)67-49-55-73-70-52-34-31-28-25-22-19-16-13-10-7-3/h59H,5-55H2,1-4H3
InChi Key
DDSMZEKGYXRVRD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 mg

    $176

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    10 mg

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    25 mg

    $704

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    Cayman Chemical
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    Product Description

    A1-28 is a disulfide bond-containing ionizable cationic lipid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Chang, J., Jiang, Y., et al. Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles. Adv. Mater. 31(33), e1902575 (2019).