A derivative of ARN22089
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Cancer

ARN25062

Item No. 39615

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-phenyl-2-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]-4-pyrimidinamine
CAS Number
3036492-85-7
Molecular Formula
C22H21F3N4
Formula Weight
398.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC(F)(F)C1=CC=CC(NC2=CC(C3=CC=CC=C3)=NC(C4CCNCC4)=N2)=C1
InChi Code
InChI=1S/C22H21F3N4/c23-22(24,25)17-7-4-8-18(13-17)27-20-14-19(15-5-2-1-3-6-15)28-21(29-20)16-9-11-26-12-10-16/h1-8,13-14,16,26H,9-12H2,(H,27,28,29)
InChi Key
NGGORHPZMJVKNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $483

    Add

    5 mg

    $2,294

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    ARN25062 is a derivative of ARN22089, an inhibitor of the protein-protein interaction between Cdc42 and p21-activated kinase (PAK).1 It inhibits the proliferation of SKM28, SK-MEL-3, WM3248, and A375 melanoma cells (IC50s = 6.1, 4.6, 9.3, and 5.1 µM, respectively) and SW480 colon cancer cells (IC50 = 5.9 µM). ARN25062 (10 mg/kg) reduces tumor growth in a patient-derived xenograft (PDX) mouse model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brindani, N., Vuong, L.M., Acquistapace, I.M., et al. Design, synthesis, in vitro and in vivo characterization of CDC42 GTPase interaction inhibitors for the treatment of cancer. J. Med. Chem. 66(8), 5981-6001 (2023).