An inhibitor of the Myc-MAX protein-protein interaction
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Apoptosis

MYCi975

Item No. 39622

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-chloro-6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3′-(trifluoromethyl)-[1,1′-biphenyl]-2-ol
CAS Number
2289691-01-4
Synonyms
  • NUCC-0200975
Molecular Formula
C25H16Cl2F6N2O2
Formula Weight
561.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
ClC(C=C1)=CC=C1COC(C=CC(C2=CC(C(F)(F)F)=NN2C)=C3O)=C3C4=CC(C(F)(F)F)=C(Cl)C=C4
InChi Code
InChI=1S/C25H16Cl2F6N2O2/c1-35-19(11-21(34-35)25(31,32)33)16-7-9-20(37-12-13-2-5-15(26)6-3-13)22(23(16)36)14-4-8-18(27)17(10-14)24(28,29)30/h2-11,36H,12H2,1H3
InChi Key
VSDFDVBYONIJLD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $193

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    10 mg

    $347

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    50 mg

    $963

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    100 mg

    $1,733

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    Cayman Chemical
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    Product Description

    MYCi975 is an inhibitor of the protein-protein interaction between Myc and Myc-associated factor X (MAX).1 It binds to Myc (Kd = 2.75 µM) and increases GSK3β-mediated Myc phosphorylation in a cell-free assay. MYCi975 (5 and 10 µM) decreases the viability of MyC-CaP and LNCaP prostate cancer cells. It induces apoptosis in a panel of 11 breast cancer cell lines when used at a concentration of 10 µM.2 In vivo, MYCi975 (100 mg/kg) reduces tumor volume in a MyC-CaP mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, H., Jain, A.D., Truica, M.I., et al. Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy. Cancer Cell 36(5), 483-497 (2019).

    2. Tang, M., O'Grady, S., Crown, J., et al. MYC as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigations with the novel MYC inhibitor, MYCi975. Breast Cancer Res. Treat. 195(2), 105-115 (2022).