Active • Host: E. coli • AA: 203 residues
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GPX1 (human, recombinant)

Item No. 39629

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Glutathione Peroxidase 1
  • GPXD
  • GSHPX1
Purity
≥95% estimated by SDS-PAGE
Source
Active recombinant human GPX1 expressed in E. coli
Amino Acids
203 residues
Formulation (Request formulation change)
25 mM Tris-HCl, pH 8.0, with 250 mM potassium chloride, 2 mM 2-mercaptoethanol, and 10% glycerol
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $439

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    100 µg

    $834

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    Cayman Chemical
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    Product Description

    Glutathione peroxidase 1 (GPX1) is a selenocysteine-containing glutathione peroxidase with antioxidant activity.1 It is ubiquitously expressed and localizes to both the cytosol and mitochondria.2 GPX1 catalyzes the reduction of hydrogen peroxide, hydroperoxy fatty acids, and hydroperoxy lysophosphatides to water or their corresponding non-toxic lipid alcohols, respectively, by converting glutathione (GSH) to oxidized glutathione (GSSG), thereby reducing intracellular oxidative stress.1,2,3 GPX1 levels are increased in renal cell carcinoma tumors compared with non-tumor renal tissue and correlated with decreased overall patient survival.4 Plasma levels of GPX1 are decreased in asthmatic patients and GPX1 SNPs are associated with an increased risk of the development of asthma.5 Cardiac GPX1 levels and whole blood GPX1 activity are decreased in patients with Keshan disease, an endemic cardiomyopathy associated with low selenium levels in the soil and food supply.6 Cayman's GPX1 (human, recombinant) protein can be used for enzyme activity assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, Y., Wang, H., Zhou, J., et al. Glutathione peroxidase GPX1 and Its dichotomous roles in cancer. Cancers (Basel) 14(10), 2560 (2022).

    2. Brigelius-Flohé, R., and Maiorino, M. Glutathione peroxidases. Biochim. Biophys. Acta 1830(5), 3289-3303 (2013).

    3. Lubos, E., Loscalzo, J., and Handy, D.E. Glutathione peroxidase-1 in health and disease: From molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 15(7), 1957-1997 (2011).

    4. Cheng, Y., Xu, T., Li, S., et al. GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer. Aging (Albany NY) 11(24), 12165-12176 (2019).

    5. Iorio, A., Velocci, M., Graziano, M.E., et al. GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients. Clin. Exp. Pharmacol. Physiol. 43(2), 277-279 (2016).

    6. Handy, D.E., and Loscalzo, J. The role of glutathione peroxidase-1 in health and disease. Free Radic. Biol. Med. 188, 146-161 (2022).